The Campus Safety Department operates 24 hours a day, seven days a week. To contact Campus Safety, call 716.286.8111 (calls may be recorded). The department is primarily responsible for enforcement of university policies which ensure good order on the main campus and the campus in Ontario. The department also provides general information and safety assistance to the campus community.

NU strives for a safe and secure campus environment. The university disseminates safety and security information through programs such as New Student Orientation, staff and student leadership training, and through various campus educational and social programs.